Post Lead Optimization

Identification of MoA for potential adverse events, incorporating
those elements into design of backup series and more

  • Molecular hypotheses for observed AEs
  • PK/PD QSAR models
  • In vitro – in vivo correlation (IVIVC) models
  • Back up series design based on learnings from primary series
  • Comprehensive review of the DMT cycle
  • Lead repurposing
  • What worked, what didn’t

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