Post Lead Optimization
Identification of MoA for potential adverse events, incorporating
those elements into design of backup series and more
Molecular hypotheses for observed AEs- PK/PD QSAR models
- In vitro – in vivo correlation (IVIVC) models
- Back up series design based on learnings from primary series
- Comprehensive review of the DMT cycle
- Lead repurposing
- What worked, what didn’t